Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374330 | 0.90 | PTPN1 (0.42) | HSD11B1DRD4DRD2PTPN1GRM2 | |
| SCHEMBL4375700 | 0.89 | KDM4E (0.39) | DRD4DRD2DRD3PTPN1GRM2 | |
| SCHEMBL4381212 | 0.89 | PTPN1 (0.43) | DRD4PTPN1GRM2ALDH1A1MAPT | |
| SCHEMBL4374699 | 0.88 | PTPN1 (0.44) | DRD4PTPN1GRM2KDM4EALDH1A1 | |
| SCHEMBL4379460 | 0.87 | PTPN1 (0.39) | PTPN1ALDH1A1MAPTNPSR1TSHR | |
| SCHEMBL3732060 | 0.86 | PTPN1 (0.52) | DRD4PTPN1GRM2HTR2AHTR2C | |
| SCHEMBL4376462 | 0.84 | PTPN1 (0.42) | HSD11B1DRD4PTPN1GRM2HTR2A | |
| SCHEMBL4374731 | 0.84 | PTPN1 (0.54) | PTPN1KDM4EALDH1A1LMNA | |
| SCHEMBL4389725 | 0.82 | PTPN1 (0.43) | PTPN1KDM4EALDH1A1GAA | |
| SCHEMBL3742273 | 0.80 | PTPN1 (0.36) | PTPN1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |