Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3732060 | 0.92 | PTPN1 (0.52) | PTPN1HTR2AHTR2CHTR2BGSK3B | |
| SCHEMBL4381212 | 0.92 | PTPN1 (0.43) | PTPN1CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL4374330 | 0.91 | PTPN1 (0.42) | PTPN1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL4376462 | 0.91 | PTPN1 (0.42) | PTPN1HTR2AHTR2CHTR2BGSK3B | |
| SCHEMBL4374731 | 0.90 | PTPN1 (0.54) | PTPN1HTR2BKDM4EALDH1A1GSK3B | |
| SCHEMBL4389725 | 0.88 | PTPN1 (0.43) | PTPN1CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL4381688 | 0.88 | HSD11B1 (0.43) | PTPN1HTR2AHTR2CKDM4EALDH1A1 | |
| SCHEMBL4382742 | 0.87 | HRH4 (0.42) | PTPN1HRH4ADRA2CALDH1A1MAPK1 | |
| SCHEMBL3742273 | 0.86 | PTPN1 (0.36) | PTPN1HTR2AHTR2CHTR2B | |
| SCHEMBL4378466 | 0.86 | PTPN1 (0.39) | PTPN1HTR2ACYP3A4TSHRDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |