Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3732060 | 0.90 | PTPN1 (0.52) | PTPN1 | |
| SCHEMBL4374699 | 0.88 | PTPN1 (0.44) | PTPN1ALDH1A1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL4381212 | 0.86 | PTPN1 (0.43) | PTPN1ALDH1A1SMN1; SMN2CYP1A2GAA | |
| SCHEMBL4376462 | 0.85 | PTPN1 (0.42) | PTPN1HRH3TRPV1 | |
| SCHEMBL4374330 | 0.85 | PTPN1 (0.42) | PTPN1ALDH1A1KDM4EKCNH2HTR1A | |
| SCHEMBL4374731 | 0.85 | PTPN1 (0.54) | PTPN1ALDH1A1KDM4E | |
| SCHEMBL4381688 | 0.82 | HSD11B1 (0.43) | PTPN1ALDH1A1KDM4EGAA | |
| SCHEMBL3732573 | 0.81 | PTPN1 (0.38) | PTPN1TRPV1 | |
| SCHEMBL4379460 | 0.81 | PTPN1 (0.39) | PTPN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3742273 | 0.81 | PTPN1 (0.36) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |