Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | HTR3A | P46098 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1372235 | 0.80 | HRH3 (0.60) | HRH3KCNH2CHRM2SLC6A2ADRA1A | |
| SCHEMBL10196775 | 0.79 | HRH3 (0.66) | HRH3KCNH2CHRM2SLC6A2ADRA1A | |
| SCHEMBL1375147 | 0.79 | HRH3 (0.59) | HRH3KCNH2CHRM2SLC6A2ADRA1A | |
| SCHEMBL1372237 | 0.79 | HRH3 (0.57) | HRH3KCNH2CHRM2SLC6A2ADRA1A | |
| SCHEMBL1375151 | 0.76 | HRH3 (0.57) | HRH3KCNH2CHRM2SLC6A2ADRA1A | |
| SCHEMBL10963711 | 0.76 | LMNA (0.65) | HRH3KCNH2CHRM2SLC6A2ADRA1A | |
| SCHEMBL3604079 | 0.76 | HRH3 (0.66) | HRH3KCNH2CHRM2SLC6A2ADRA1A | |
| SCHEMBL9815940 | 0.75 | MAPT (0.64) | HRH3KCNH2CHRM2SLC6A2ADRA1A | |
| Irdabisant SCHEMBL1376185 | 0.75 | HRH3 (1.00) | HRH3KCNH2CHRM2SLC6A2ADRA1A | |
| Irdabisant SCHEMBL117723 | 0.75 | HRH3 (1.00) | HRH3KCNH2CHRM2SLC6A2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |