Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3006611 | 0.96 | FAAH (0.46) | FAAHCNR2HTTMEN1KMT2A | |
| SCHEMBL3005497 | 0.95 | FAAH (0.46) | FAAHCNR2HTTMEN1KMT2A | |
| SCHEMBL3005859 | 0.95 | S1PR3 (0.44) | FAAHCNR2HTTTP53S1PR3 | |
| SCHEMBL2996457 | 0.94 | S1PR3 (0.44) | CNR2HTTMEN1KMT2ATP53 | |
| SCHEMBL4391954 | 0.93 | FAAH (0.45) | FAAHCNR2HTTMEN1KMT2A | |
| SCHEMBL3006284 | 0.93 | FAAH (0.46) | FAAHCNR2HTTMEN1KMT2A | |
| SCHEMBL3010320 | 0.92 | S1PR3 (0.42) | FAAHHTTMEN1KMT2ATP53 | |
| SCHEMBL2999872 | 0.92 | FAAH (0.47) | FAAHCNR2HTTMEN1KMT2A | |
| SCHEMBL3001499 | 0.91 | S1PR3 (0.42) | FAAHCNR2HTTMEN1KMT2A | |
| SCHEMBL4386783 | 0.90 | FAAH (0.46) | FAAHCNR2HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |