SCHEMBL4381948

SCHEMBL4381948

COc1ccc(NC(=O)CCCl)cc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.75
ALDH1A1 P00352 6/20 0.71
HTT P42858 1/20 0.71
HDAC3 O15379 2/20 0.67
HDAC4 P56524 2/20 0.67
HDAC1 Q13547 2/20 0.67
HDAC7 Q8WUI4 2/20 0.67
HDAC2 Q92769 2/20 0.67
HDAC10 Q969S8 2/20 0.67
HDAC11 Q96DB2 2/20 0.67
HDAC8 Q9BY41 2/20 0.67
HDAC6 Q9UBN7 2/20 0.67
HDAC9 Q9UKV0 2/20 0.67
HDAC5 Q9UQL6 2/20 0.67
LMNA P02545 1/20 0.63
KMT2A Q03164 7/20 0.61
MEN1 O00255 6/20 0.61
RAB9A P51151 3/20 0.61
SMN1; SMN2 Q16637 3/20 0.61
MAPT P10636 3/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8277402 0.88 L3MBTL1 (0.77) L3MBTL1ALDH1A1HTTHDAC3HDAC4
SCHEMBL1289638 0.86 L3MBTL1 (0.69) L3MBTL1ALDH1A1HTTHDAC3HDAC4
SCHEMBL147292 0.84 L3MBTL1 (0.77) L3MBTL1ALDH1A1HTTHDAC3HDAC4
SCHEMBL147293 0.84 L3MBTL1 (0.77) L3MBTL1ALDH1A1HTTHDAC3HDAC4
SCHEMBL9313874 0.83 L3MBTL1 (0.76) L3MBTL1ALDH1A1HTTHDAC3HDAC4
SCHEMBL16438801 0.83 L3MBTL1 (0.75) L3MBTL1ALDH1A1HTTHDAC3HDAC4
SCHEMBL11147480 0.83 L3MBTL1 (0.75) L3MBTL1ALDH1A1HTTHDAC3HDAC4
SCHEMBL7827827 0.83 ALDH1A1 (0.76) L3MBTL1ALDH1A1HTTHDAC3HDAC4
SCHEMBL23748676 0.81 RNF4 (0.73) L3MBTL1ALDH1A1HTTHDAC3HDAC4
SCHEMBL22931143 0.81 L3MBTL1 (0.63) L3MBTL1ALDH1A1HTTHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111285803-B Preparation method of 6-hydroxy-3, 4-dihydro-2 (1H) -quinolone 湖南复瑞生物医药技术有限责任公司 2024-04-09 CN claimed
CN-111285803-A Preparation method of 6-hydroxy-3, 4-dihydro-2 (1H) -quinolone 湖南复瑞生物医药技术有限责任公司 2020-06-16 CN claimed
US-6740758-B2 REACTING P-ANISIDINE WITH 3-CHLOROPROPIONYL CHLORIDE IN PRESENCE OF SODIUM BICARBONATE AND TOLUENE AND CYCLIZING TEVA PHARMACEUTICAL INDUSTRIES (IL) 2004-05-25 US claimed
US-20040034228-A1 Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide MENDELOVICI MARIOARA (IL) 2004-02-19 US claimed
US-6660773-B2 Reacting anisidine with 3-chloropropionamide to form N-(4-methoxy phenyl)-3-chloropropionamide; intramolecular Friedel-Crafts cyclization with a Lewis acid; decomposition of salt; demethylation TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 2003-12-09 US claimed
US-20030176703-A1 Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide MENDELOVICI MARIOARA (IL) 2003-09-18 US claimed
US-6525201-B2 Amidation of p-anisidine with 3-chloropropionyl chloride; cyclization and demtylation of n-(4-methoxyphenyl)-3-chloropropionamide; optimal base/solvent combinations TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 2003-02-25 US claimed
US-20020137936-A1 Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)3-chloropropionamide MENDELOVICI MARIOARA (IL) 2002-09-26 US claimed
US-20020032333-A1 Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide TEVA PHARMACEUTICAL USA, INC. 2002-03-14 US claimed
WO-2001070697-A1 PROCESSES FOR PREPARING 6-HYDROXY-3,4-DIHYDROQUINOLINONE, CILOSTAZOL AND N-(4-METHOXYPHENYL)-3-CHLOROPROPIONAMIDE TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2001-09-27 WO claimed
CN-111285803-B Preparation method of 6-hydroxy-3, 4-dihydro-2 (1H) -quinolone 湖南复瑞生物医药技术有限责任公司 2024-04-09 CN disclosed
CN-111285803-B Preparation method of 6-hydroxy-3, 4-dihydro-2 (1H) -quinolone 湖南复瑞生物医药技术有限责任公司 2024-04-09 CN disclosed
CN-111285803-A Preparation method of 6-hydroxy-3, 4-dihydro-2 (1H) -quinolone 湖南复瑞生物医药技术有限责任公司 2020-06-16 CN disclosed
CN-111285803-A Preparation method of 6-hydroxy-3, 4-dihydro-2 (1H) -quinolone 湖南复瑞生物医药技术有限责任公司 2020-06-16 CN disclosed
US-8779146-B2 Cilostazol cocrystals and compositions NUFORMIX LIMITED (GB) 2014-07-15 US disclosed
WO-2001070697-A1 PROCESSES FOR PREPARING 6-HYDROXY-3,4-DIHYDROQUINOLINONE, CILOSTAZOL AND N-(4-METHOXYPHENYL)-3-CHLOROPROPIONAMIDE TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2001-09-27 WO disclosed
WO-2001070697-A1 PROCESSES FOR PREPARING 6-HYDROXY-3,4-DIHYDROQUINOLINONE, CILOSTAZOL AND N-(4-METHOXYPHENYL)-3-CHLOROPROPIONAMIDE TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2001-09-27 WO disclosed
US-4058532-A 1-Phenyl-3,4-dihydrocarbostyrils STERLING DRUG INC. (US) 1977-11-15 US disclosed
US-4049715-A 3-[2-(4-Anisidino)phenyl]-1-phenyl-1-propiophenones and propanols STERLING DRUG INC. (US) 1977-09-20 US disclosed
US-3994902-A Certain 1,2-diphenyl-1,2,3,4-tetrahydroquinoline compounds STERLING DRUG INC. (US) 1976-11-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040034228-A1 Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide HRH2, HRH3, HRH4 L3MBTL1 4357/4885ALDH1A1 203/4885HTT 799/4885
US-20030176703-A1 Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide HRH2, HRH3, HRH4 L3MBTL1 4357/4885ALDH1A1 203/4885HTT 799/4885
US-20020137936-A1 Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)3-chloropropionamide HRH2, HRH3, PDE8B L3MBTL1 4292/4885ALDH1A1 145/4885HTT 514/4885
US-20020032333-A1 Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and N-(4-methoxyphenyl)-3-chloropropionamide HRH2, HRH3, HRH4 L3MBTL1 4357/4885ALDH1A1 203/4885HTT 799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.