Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 10/20 | 0.69 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.69 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | PGR | P06401 | 1/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.69 |
| ▸ | PDE4A | P27815 | 1/20 | 0.69 |
| ▸ | BLVRB | P30043 | 1/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.69 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14103305 | 0.89 | XDH (0.67) | XDHTARBP2ABCC4ABCB11PGR | |
| SCHEMBL28504761 | 0.88 | XDH (0.57) | XDHTARBP2ABCC4ABCB11PGR | |
| SCHEMBL20195725 | 0.86 | XDH (0.66) | XDHTARBP2ABCC4ABCB11PGR | |
| SCHEMBL4382151 | 0.85 | XDH (0.53) | XDHTARBP2ABCC4ABCB11PGR | |
| Febuxostat SCHEMBL29398803 | 0.82 | XDH (1.00) | XDHTARBP2ABCC4ABCB11PGR | |
| Febuxostat SCHEMBL28271887 | 0.82 | XDH (1.00) | XDHTARBP2ABCC4ABCB11PGR | |
| SCHEMBL19523323 | 0.82 | XDH (0.66) | XDHTARBP2ABCC4ABCB11PGR | |
| Febuxostat SCHEMBL30161803 | 0.82 | XDH (1.00) | XDHTARBP2ABCC4ABCB11PGR | |
| Febuxostat SCHEMBL249339 | 0.82 | XDH (1.00) | XDHTARBP2ABCC4ABCB11PGR | |
| SCHEMBL438271 | 0.81 | XDH (0.68) | XDHTARBP2ABCC4ABCB11PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102020617-B | The polymorphs body and preparation method thereof of 2- (3- cyano-4-isobutoxy phenyl) -4- methyl-5-thiazole formic acid | 帝人制药株式会社 | 2019-04-23 | — | — | CN | disclosed |
| CN-103788009-A | Febuxostat polymorph and preparation method thereof | UNIV SOUTH CHINA TECH | 2014-05-14 | — | — | CN | disclosed |
| EP-1020454-B2 | POLYMORPHIC MODIFICATIONS OF 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID AND PROCESSES FOR THE PREPARATION THEREOF | TEIJIN PHARMA LTD (JP) | 2013-01-23 | — | — | EP | disclosed |
| CN-101768136-A | New crystal form of febuxostat and preparation method thereof | BEIJING D VENTUREPHARM TECHNOL | 2010-07-07 | — | — | CN | disclosed |
| EP-1020454-B1 | POLYMORPHIC MODIFICATIONS OF 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID AND PROCESSES FOR THE PREPARATION THEREOF | TEIJIN PHARMA LTD (JP) | 2009-11-25 | — | — | EP | disclosed |
| EP-1020454-A4 | POLYMORPHIC MODIFICATIONS OF 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID AND PROCESSES FOR THE PREPARATION THEREOF | TEIJIN LTD (JP) | 2002-05-15 | — | — | EP | disclosed |
| EP-1020454-A1 | POLYMORPHIC MODIFICATIONS OF 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID AND PROCESSES FOR THE PREPARATION THEREOF | TEIJIN LIMITED (JP) | 2000-07-19 | — | — | EP | disclosed |