Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPY2R | P49146 | 2/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346486 | 0.88 | NPC1 (0.58) | NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL346770 | 0.87 | NPC1 (0.38) | NPC1RAB9ANPY2RGHSRUSP2 | |
| SCHEMBL346598 | 0.84 | KHK (0.40) | NPC1RAB9AGHSRUSP2RXFP1 | |
| SCHEMBL345519 | 0.84 | NPC1 (0.58) | NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL345716 | 0.80 | KHK (0.40) | NPC1RAB9AGHSRRXFP1KMT2A | |
| SCHEMBL438194 | 0.79 | KMT2A (0.45) | NPC1RAB9AGHSRUSP2RXFP1 | |
| SCHEMBL346653 | 0.78 | NPC1 (0.56) | NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL10197813 | 0.78 | DRD2 (0.39) | GHSRKMT2ADRD2OPRM1OPRD1 | |
| SCHEMBL346641 | 0.76 | GHSR (0.49) | NPC1RAB9AGHSRUSP2RXFP1 | |
| SCHEMBL436430 | 0.76 | GHSR (0.42) | NPC1RAB9AGHSRKMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012320-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENIUM PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | WO | disclosed |