Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 3/20 | 0.55 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.55 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.55 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.55 |
| ▸ | SLC28A1 | O00337 | 2/20 | 0.55 |
| ▸ | SLC28A2 | O43868 | 2/20 | 0.55 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.55 |
| ▸ | SLC28A3 | Q9HAS3 | 2/20 | 0.55 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.55 |
| ▸ | DPP4 | P27487 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.55 |
| ▸ | GAPDH | P04406 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | STAT6 | P42226 | 1/20 | 0.55 |
| ▸ | PI4KA | P42356 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.55 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL8023430 | 0.95 | ADORA3 (0.61) | ADORA3SLC28A1SLC28A2SLC29A1SLC28A3 | |
| Guanosine SCHEMBL27658690 | 0.91 | RNASEL (0.51) | ADORA3SLC28A1SLC28A2SLC29A1SLC28A3 | |
| Adenosine SCHEMBL17363794 | 0.87 | ADORA3 (0.72) | ADORA3SLC28A1SLC28A2SLC29A1SLC28A3 | |
| Uridine SCHEMBL3351395 | 0.87 | SLC28A1 (0.65) | SLC28A1SLC28A2SLC29A1SLC28A3RNASEL | |
| Adenosine SCHEMBL2248919 | 0.86 | ADORA3 (0.74) | ADORA3SLC28A1SLC28A2SLC29A1SLC28A3 | |
| Adenosine SCHEMBL8351411 | 0.86 | ADORA3 (0.74) | ADORA3SLC28A1SLC28A2SLC29A1SLC28A3 | |
| Adenosine SCHEMBL15753116 | 0.86 | ADORA3 (0.56) | ADORA3SLC28A1SLC28A2SLC29A1SLC28A3 | |
| Adenosine SCHEMBL8023428 | 0.85 | ADORA3 (0.64) | ADORA3SLC28A1SLC28A2SLC29A1SLC28A3 | |
| Adenosine SCHEMBL536559 | 0.85 | ADORA3 (0.77) | ADORA3SLC28A1SLC28A2SLC29A1SLC28A3 | |
| Adenosine SCHEMBL9591334 | 0.83 | ADORA3 (0.67) | ADORA3SLC28A1SLC28A2SLC29A1SLC28A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021043-A1 | Nucleic Acids Comprising formula (NuGlXmGnNv)a and Derivatives Thereof as Immunostimulating Agent/Adjuvant | CureVac GmbHÛ (DE) | 2012-01-26 | — | — | US | disclosed |
| US-20110250225-A1 | COMPOSITION COMPRISING A COMPLEXED (M)RNA AND A NAKED MRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF | CUREVAC GMBH | 2011-10-13 | — | — | US | disclosed |
| EP-2331129-A1 | COMPOSITION COMPRISING A COMPLEXED (M)RNA AND A NAKED MRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF | Curevac GmbH (DE) | 2011-06-15 | — | — | EP | disclosed |