Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 4/20 | 0.33 |
| ▸ | FNTB | P49356 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1289601 | 0.92 | L3MBTL1 (0.41) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL3153974 | 0.92 | PLA2G1B (0.38) | ALDH1A1HPGDHSD17B10PLA2G1BATG4B | |
| SCHEMBL2228571 | 0.91 | L3MBTL1 (0.37) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL1922242 | 0.86 | L3MBTL1 (0.40) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL2552584 | 0.85 | L3MBTL1 (0.48) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL516264 | 0.83 | PLA2G1B (0.41) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL1922260 | 0.82 | PLA2G1B (0.43) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL2551044 | 0.78 | RXFP1 (0.52) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL1923354 | 0.76 | L3MBTL1 (0.40) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| Ranelic Acid SCHEMBL500994 | 0.76 | FNTA (0.37) | PLA2G1BATG4BFNTAFNTBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1403265-B1 | Industrial process for the synthesis of 5-¬bis(carboxymethyl)amino -3-carboxymethyl-4-cyano-2-thiophene-carboxylic acid tetraesters and use for the synthesis of ranetic acid divalent salts and hydrates thereof | SERVIER LAB (FR) | 2009-11-25 | — | — | EP | claimed |
| WO-2004029034-A1 | SYNTHESIS OF THIOPHENECARBOXYLIC ACID ESTERS FOR THE PRODUCTION OF RANELIC ACID SALTS | LES LABORATOIRES SERVIER (FR) | 2004-04-08 | — | — | WO | claimed |
| EP-1403265-A1 | Industrial process for the synthesis of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophene-carboxylic acid tetraesters and use for the synthesis of ranetic acid divalent salts and hydrates thereof | Les Laboratoires Servier (FR) | 2004-03-31 | — | — | EP | claimed |
| EP-1403265-B1 | Industrial process for the synthesis of 5-¬bis(carboxymethyl)amino -3-carboxymethyl-4-cyano-2-thiophene-carboxylic acid tetraesters and use for the synthesis of ranetic acid divalent salts and hydrates thereof | SERVIER LAB (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2004029034-A1 | SYNTHESIS OF THIOPHENECARBOXYLIC ACID ESTERS FOR THE PRODUCTION OF RANELIC ACID SALTS | LES LABORATOIRES SERVIER (FR) | 2004-04-08 | — | — | WO | disclosed |
| WO-2004029036-A1 | NOVEL METHOD FOR THE INDUSTRIAL SYNTHESIS OF STRONTIUM RANELATE AND THE HYDRATES THEREOF | LES LABORATOIRES SERVIER (FR) | 2004-04-08 | — | — | WO | disclosed |
| EP-1403265-A1 | Industrial process for the synthesis of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophene-carboxylic acid tetraesters and use for the synthesis of ranetic acid divalent salts and hydrates thereof | Les Laboratoires Servier (FR) | 2004-03-31 | — | — | EP | disclosed |
| EP-1403266-A1 | Process for the industrial synthesis of strontium ranelate and hydrates thereof | LES LABORATOIRES SERVIER (FR) | 2004-03-31 | — | — | EP | disclosed |