Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 3/20 | 0.35 |
| ▸ | FNTB | P49356 | 3/20 | 0.35 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.35 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.35 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382831 | 0.92 | ALDH1A1 (0.37) | L3MBTL1RXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL1922242 | 0.92 | L3MBTL1 (0.40) | L3MBTL1RXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL516264 | 0.92 | PLA2G1B (0.41) | L3MBTL1RXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL2552584 | 0.91 | L3MBTL1 (0.48) | L3MBTL1RXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL1922260 | 0.88 | PLA2G1B (0.43) | L3MBTL1RXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL1923354 | 0.84 | L3MBTL1 (0.40) | L3MBTL1RXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL2551044 | 0.83 | RXFP1 (0.52) | L3MBTL1RXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL3153974 | 0.83 | PLA2G1B (0.38) | ALDH1A1HPGDHSD17B10PLA2G1BATG4B | |
| SCHEMBL2228571 | 0.82 | L3MBTL1 (0.37) | L3MBTL1RXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL2553694 | 0.79 | RXFP1 (0.53) | L3MBTL1RXFP1ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1403265-B1 | Industrial process for the synthesis of 5-¬bis(carboxymethyl)amino -3-carboxymethyl-4-cyano-2-thiophene-carboxylic acid tetraesters and use for the synthesis of ranetic acid divalent salts and hydrates thereof | SERVIER LAB (FR) | 2009-11-25 | — | — | EP | claimed |
| US-20040059134-A1 | Process for the industrial synthesis of tetraesters of 5-[BIS(CARBOXYMETHYL)AMINO]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2004-03-25 | — | — | US | claimed |
| US-20120123131-A1 | PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE | PRABAHAR KOILPILLAI JOSEPH (IN) | 2012-05-17 | — | — | US | disclosed |
| WO-2012046251-A2 | NOVEL FORM OF RANELIC ACID | GLENMARK GENERICS LIMITED (IN) | 2012-04-12 | — | — | WO | disclosed |
| WO-2012046251-A2 | NOVEL FORM OF RANELIC ACID | GLENMARK GENERICS LIMITED (IN) | 2012-04-12 | — | — | WO | disclosed |
| EP-2328884-A2 | A PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE | Glenmark Generics Limited (IN) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010021000-A2 | A PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE | GLENMARK GENERICS LIMITED (IN) | 2010-02-25 | — | — | WO | disclosed |
| US-7214805-B2 | Process for the industrial synthesis of strontium ranelate and its hydrates | LES LABORATOIRES SERVIER (FR) | 2007-05-08 | — | — | US | disclosed |
| US-7091364-B2 | Process for the industrial synthesis of tetraesters of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2006-08-15 | — | — | US | disclosed |
| US-20040063972-A1 | Process for the industrial synthesis of strontium ranelate and its hydrates | LES LABORATOIRES SERVIER (FR) | 2004-04-01 | — | — | US | disclosed |
| EP-1403265-A1 | Industrial process for the synthesis of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophene-carboxylic acid tetraesters and use for the synthesis of ranetic acid divalent salts and hydrates thereof | Les Laboratoires Servier (FR) | 2004-03-31 | — | — | EP | disclosed |
| US-20040059134-A1 | Process for the industrial synthesis of tetraesters of 5-[BIS(CARBOXYMETHYL)AMINO]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063972-A1 | Process for the industrial synthesis of strontium ranelate and its hydrates | STAU1, SF1, CYP51A1 | L3MBTL1 4527/4885RXFP1 2914/4885ALDH1A1 938/4885 |
| US-20040059134-A1 | Process for the industrial synthesis of tetraesters of 5-[BIS(CARBOXYMETHYL)AMINO]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | CA7, SLC6A6, CA6 | L3MBTL1 4454/4885RXFP1 2210/4885ALDH1A1 1492/4885 |
| US-20120123131-A1 | PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE | C1S, RANBP1, C5 | L3MBTL1 4008/4885RXFP1 2087/4885ALDH1A1 2317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.