Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259069 | 0.97 | CYP4F2 (0.46) | SIRT2SMN1; SMN2CYP4F2CYP4A11POLB | |
| SCHEMBL2034215 | 0.93 | SIRT2 (0.46) | SIRT2SMN1; SMN2CYP4F2CYP4A11POLB | |
| SCHEMBL13262679 | 0.88 | SIRT2 (0.48) | SIRT2 | |
| SCHEMBL6777569 | 0.85 | SIRT2 (0.48) | SIRT2 | |
| SCHEMBL9263718 | 0.84 | SIRT2 (0.45) | SIRT2SMN1; SMN2 | |
| SCHEMBL29556807 | 0.83 | SIRT2 (0.44) | SIRT2SMN1; SMN2 | |
| SCHEMBL1037593 | 0.81 | SIRT2 (0.50) | SIRT2 | |
| SCHEMBL7705897 | 0.80 | SIRT2 (0.44) | SIRT2 | |
| SCHEMBL4789448 | 0.80 | NR1I2 (0.41) | SIRT2SMN1; SMN2CYP4F2CYP4A11POLB | |
| SCHEMBL2796109 | 0.80 | SIRT2 (0.52) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |