Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682557 | 0.94 | SMN1; SMN2 (0.43) | SMN1; SMN2CYSLTR2CYSLTR1POLBALDH1A1 | |
| SCHEMBL1310533 | 0.85 | TOP1 (0.42) | ADORA3CYSLTR2CYSLTR1TBXAS1ALDH1A1 | |
| SCHEMBL1310531 | 0.85 | TOP1 (0.42) | ADORA3CYSLTR2CYSLTR1TBXAS1ALDH1A1 | |
| SCHEMBL29055933 | 0.82 | TBXAS1 (0.44) | CYSLTR2CYSLTR1TBXAS1 | |
| SCHEMBL25311000 | 0.82 | TBXAS1 (0.44) | CYSLTR2CYSLTR1TBXAS1 | |
| SCHEMBL29055928 | 0.81 | TBXAS1 (0.43) | CYSLTR2CYSLTR1TBXAS1ALDH1A1 | |
| SCHEMBL25388228 | 0.81 | TBXAS1 (0.43) | CYSLTR2CYSLTR1TBXAS1ALDH1A1 | |
| SCHEMBL30521349 | 0.81 | TBXAS1 (0.43) | CYSLTR2CYSLTR1TBXAS1ALDH1A1 | |
| SCHEMBL25311135 | 0.81 | TBXAS1 (0.43) | CYSLTR2CYSLTR1TBXAS1ALDH1A1 | |
| SCHEMBL25307567 | 0.81 | FABP4 (0.39) | TBXAS1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318994-B1 | SUBSTITUTED IMIDAZOLES AS DUAL HISTAMINE H1 AND H3 AGONISTS OR ANTAGONISTS | SCHERING CORP (US) | 2008-02-27 | — | — | EP | disclosed |
| US-6506756-B2 | For treatment of allergies, inflammatory and central nervous system related diseases | SCHERING CORPORATION | 2003-01-14 | — | — | US | disclosed |
| US-20020086859-A1 | Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists | SCHERING CORPORATION | 2002-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020086859-A1 | Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists | HRH3, HRH4, HRH2 | NR1I2 1251/4885PGR 1647/4885ADORA3 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.