SCHEMBL4383880

SCHEMBL4383880

COc1ccc(C(C)(C)c2ccc(O)c(C(=O)Oc3ccccc3)c2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 11/20 0.50
HSD17B10 Q99714 4/20 0.50
HPGD P15428 4/20 0.50
ALOX15 P16050 2/20 0.50
NPSR1 Q6W5P4 1/20 0.50
TDP1 Q9NUW8 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
TP53 P04637 4/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
LMNA P02545 3/20 0.44
CYP3A4 P08684 2/20 0.44
ADORA3 P0DMS8 2/20 0.44
CHRM1 P11229 2/20 0.44
TBXA2R P21731 2/20 0.44
SLC6A2 P23975 2/20 0.44
ADRA1A P35348 2/20 0.44
PDE4A P27815 1/20 0.44
KDR P35968 1/20 0.44
SLC6A3 Q01959 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11387862 0.92 HSD17B10 (0.51) MAPTHSD17B10HPGDALOX15NPSR1
SCHEMBL4395930 0.91 HSD17B10 (0.51) MAPTHSD17B10HPGDALOX15NPSR1
SCHEMBL7056539 0.91 HSD17B10 (0.51) MAPTHSD17B10HPGDALOX15NPSR1
SCHEMBL4390475 0.90 HSD17B10 (0.48) MAPTHSD17B10HPGDALOX15NPSR1
SCHEMBL4384821 0.90 HSD17B10 (0.53) MAPTHSD17B10HPGDALOX15NPSR1
SCHEMBL20085521 0.86 MAPT (0.41) MAPTHSD17B10HPGDALOX15NPSR1
SCHEMBL4391329 0.86 CA12 (0.46) MAPTHSD17B10HPGDALOX15NPSR1
SCHEMBL4395924 0.85 CA1 (0.53) MAPTHSD17B10HPGDALOX15TDP1
SCHEMBL15827155 0.84 MAPT (0.45) MAPTHSD17B10HPGDALOX15NPSR1
SCHEMBL12443402 0.84 HSD17B10 (0.58) MAPTHSD17B10HPGDALOX15NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1829854-B1 PROCESS FOR PRODUCING AROMATIC CARBONATE ASAHI KASEI CHEMICALS CORP (JP) 2013-09-04 EP disclosed
US-7629485-B2 Process for producing aromatic carbonate ASAHI KASEI CHEMICALS CORPORATION (JP) 2009-12-08 US disclosed
US-20080177099-A1 Process for Producing Aromatic Carbonate ASAHI KASEI KABUSHIKI KAISHA (JP) 2008-07-24 US disclosed
EP-1829854-A1 PROCESS FOR PRODUCING AROMATIC CARBONATE Asahi Kasei Chemicals Corporation (JP) 2007-09-05 EP disclosed
EP-1016648-B1 PROCESS FOR THE PREPARATION OF AROMATIC CARBONATES ASAHI CHEMICAL IND (JP) 2003-05-14 EP disclosed
US-6262210-B1 TRANSESTERIFYING DIALKYL CARBONATE, ALKYL ARYL CARBONATE OR MIXTURE WITH AROMATIC MONOHYDROXY COMPOUND IN PRESENCE OF METAL CONTAINING CATALYST TO OBTAIN HIGH BOILING POINT REACTION MIXTURE CONTAINING AROMATIC CARBONATE ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 2001-07-17 US disclosed
EP-1016648-A1 PROCESS FOR THE PREPARATION OF AROMATIC CARBONATES Asahi Kasei Kogyo Kabushiki Kaisha (JP) 2000-07-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080177099-A1 Process for Producing Aromatic Carbonate DCLK1, ALK, DCLK3 MAPT 1301/4885HSD17B10 963/4885HPGD 3545/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.