SCHEMBL4390475

SCHEMBL4390475

COC(=O)Oc1ccc(C(C)(C)c2ccc(O)c(C(=O)Oc3ccccc3)c2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 5/20 0.48
HPGD P15428 4/20 0.48
ALOX15 P16050 2/20 0.48
MAPT P10636 8/20 0.45
NPSR1 Q6W5P4 1/20 0.45
EGFR P00533 2/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
KDM4E B2RXH2 7/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
POLB P06746 2/20 0.43
CYP2D6 P10635 2/20 0.43
ATM Q13315 1/20 0.43
MAPK1 P28482 2/20 0.43
LMNA P02545 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
TP53 P04637 2/20 0.42
CYP3A4 P08684 1/20 0.42
ADORA3 P0DMS8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7056539 0.94 HSD17B10 (0.51) HSD17B10HPGDALOX15MAPTNPSR1
SCHEMBL4391329 0.91 CA12 (0.46) HSD17B10HPGDALOX15MAPTNPSR1
SCHEMBL4383880 0.90 MAPT (0.50) HSD17B10HPGDALOX15MAPTNPSR1
SCHEMBL4541202 0.90 CA12 (0.49) HSD17B10HPGDMAPTNPSR1EGFR
SCHEMBL11387862 0.90 HSD17B10 (0.51) HSD17B10HPGDALOX15MAPTNPSR1
SCHEMBL4395930 0.89 HSD17B10 (0.51) HSD17B10HPGDALOX15MAPTNPSR1
SCHEMBL4384821 0.87 HSD17B10 (0.53) HSD17B10HPGDALOX15MAPTNPSR1
SCHEMBL4541151 0.83 HPGD (0.44) HSD17B10HPGDALOX15MAPTNPSR1
SCHEMBL19846658 0.83 TDP1 (0.49) HSD17B10HPGDMAPTNPSR1TDP1
SCHEMBL15827155 0.82 MAPT (0.45) HSD17B10HPGDALOX15MAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1829854-B1 PROCESS FOR PRODUCING AROMATIC CARBONATE ASAHI KASEI CHEMICALS CORP (JP) 2013-09-04 EP disclosed
US-7629485-B2 Process for producing aromatic carbonate ASAHI KASEI CHEMICALS CORPORATION (JP) 2009-12-08 US disclosed
US-20080177099-A1 Process for Producing Aromatic Carbonate ASAHI KASEI KABUSHIKI KAISHA (JP) 2008-07-24 US disclosed
EP-1829854-A1 PROCESS FOR PRODUCING AROMATIC CARBONATE Asahi Kasei Chemicals Corporation (JP) 2007-09-05 EP disclosed
EP-1016648-B1 PROCESS FOR THE PREPARATION OF AROMATIC CARBONATES ASAHI CHEMICAL IND (JP) 2003-05-14 EP disclosed
US-6262210-B1 TRANSESTERIFYING DIALKYL CARBONATE, ALKYL ARYL CARBONATE OR MIXTURE WITH AROMATIC MONOHYDROXY COMPOUND IN PRESENCE OF METAL CONTAINING CATALYST TO OBTAIN HIGH BOILING POINT REACTION MIXTURE CONTAINING AROMATIC CARBONATE ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 2001-07-17 US disclosed
EP-1016648-A1 PROCESS FOR THE PREPARATION OF AROMATIC CARBONATES Asahi Kasei Kogyo Kabushiki Kaisha (JP) 2000-07-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080177099-A1 Process for Producing Aromatic Carbonate DCLK1, ALK, DCLK3 HSD17B10 963/4885HPGD 3545/4885ALOX15 4154/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.