Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 3/20 | 0.34 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384107 | 1.00 | ITGB3 (0.42) | ITGB3ITGAVCA2CA12CA1 | |
| SCHEMBL2832886 | 0.85 | ITGB3 (0.47) | ITGB3ITGAVALDH1A1PKMHDAC8 | |
| SCHEMBL2841991 | 0.82 | LMNA (0.49) | CA2CA12CA1CA9ALDH1A1 | |
| SCHEMBL2833089 | 0.80 | ITGB3 (0.48) | ITGB3ITGAVALDH1A1PKMHDAC8 | |
| SCHEMBL2836439 | 0.80 | ITGB3 (0.45) | ITGB3ITGAVALDH1A1HDAC8HDAC6 | |
| SCHEMBL2839356 | 0.78 | NAMPT (0.47) | ITGB3ITGAVLMNANAMPTSMN1; SMN2 | |
| SCHEMBL2839446 | 0.76 | HDAC1 (0.45) | ALDH1A1HDAC8HDAC6LMNANAMPT | |
| SCHEMBL2835299 | 0.76 | ITGB3 (0.55) | ITGB3ITGAVCA2CA12CA1 | |
| SCHEMBL2834642 | 0.74 | NAMPT (0.48) | ITGB3ITGAVLMNANAMPTHTT | |
| SCHEMBL2838359 | 0.73 | NAMPT (0.45) | ITGB3ITGAVLMNANAMPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061448-A9 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROTEINURIC DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |