Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 11/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.60 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.55 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.55 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.55 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.55 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.55 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384642 | 1.00 | LMNA (0.63) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL4384643 | 1.00 | LMNA (0.63) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL4382470 | 0.91 | LMNA (0.61) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL4382476 | 0.91 | LMNA (0.61) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL4382469 | 0.91 | LMNA (0.61) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL4805534 | 0.91 | LMNA (0.65) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL4805521 | 0.91 | LMNA (0.65) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL13853369 | 0.91 | LMNA (0.65) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL4805543 | 0.91 | LMNA (0.65) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL4806268 | 0.90 | LMNA (0.64) | LMNAALDH1A1TP53MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537135-B1 | ADENOSINE A3 RECEPTOR AGONISTS | CV THERAPEUTICS INC (US) | 2009-11-25 | — | — | EP | disclosed |
| US-6914053-B2 | Adenosine A3 receptor agonists | CV THERAPEUTICS, INC. (US) | 2005-07-05 | — | — | US | disclosed |
| EP-1537135-A2 | ADENOSINE A3 RECEPTOR AGONISTS | CV THERAPEUTICS, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040121978-A1 | Adenosine A3 receptor agonists | CV THERAPEUTICS, INC. | 2004-06-24 | — | — | US | disclosed |
| WO-2004022573-A2 | ADENOSINE A3 RECEPTOR AGONISTS | CV THERAPEUTICS, INC. (US) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121978-A1 | Adenosine A3 receptor agonists | ADORA3, ADORA2A, ADORA1 | LMNA 2972/4885ALDH1A1 811/4885TP53 1698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.