Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | DRD5 | P21918 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3173969 | 0.86 | ABCB1 (0.68) | TDP1SLC6A2SLC6A4SLC6A3ABCB1 | |
| SCHEMBL22099626 | 0.86 | SLC6A2 (0.55) | TDP1SLC6A2SLC6A4SLC6A3ABCB1 | |
| SCHEMBL10675568 | 0.85 | ABCB1 (0.67) | TDP1SLC6A2SLC6A4SLC6A3ABCB1 | |
| SCHEMBL3246821 | 0.84 | DRD1 (0.58) | TDP1SLC6A2SLC6A4SLC6A3ABCB1 | |
| SCHEMBL3655159 | 0.83 | HRH3 (0.61) | SLC6A2SLC6A4SLC6A3ABCB1HRH3 | |
| SCHEMBL22099631 | 0.83 | DRD1 (0.57) | TDP1SLC6A2SLC6A4SLC6A3ABCB1 | |
| SCHEMBL915006 | 0.82 | DRD1 (0.59) | SLC6A2SLC6A4SLC6A3ABCB1DRD1 | |
| SCHEMBL29651184 | 0.82 | DRD1 (0.59) | SLC6A2SLC6A4SLC6A3ABCB1DRD1 | |
| SCHEMBL3245091 | 0.82 | SLC6A4 (0.52) | TDP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4390875 | 0.81 | ABCB1 (0.74) | SLC6A4ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144405-B1 | TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY | ABBOTT GMBH & CO KG (DE) | 2009-11-25 | — | — | EP | disclosed |
| US-6602867-B1 | Triazole compounds with dopamine-D3-receptor affinity | ABBOTT LABORATORIES | 2003-08-05 | — | — | US | disclosed |