Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 3/20 | 0.59 |
| ▸ | DRD5 | P21918 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29651184 | 1.00 | DRD1 (0.59) | DRD1DRD5DRD3DRD2PRMT5 | |
| SCHEMBL6369681 | 0.89 | HRH3 (0.61) | DRD1DRD5DRD3DRD2PRMT5 | |
| SCHEMBL3246821 | 0.86 | DRD1 (0.58) | DRD1DRD5DRD3DRD2PRMT5 | |
| Hydrochloric Acid SCHEMBL5609445 | 0.86 | DRD1 (0.55) | DRD1DRD5DRD3DRD2PRMT5 | |
| SCHEMBL24507687 | 0.84 | DRD1 (0.54) | DRD1DRD5DRD3DRD2PRMT5 | |
| SCHEMBL3655159 | 0.84 | HRH3 (0.61) | DRD1DRD5DRD3DRD2PRMT5 | |
| SCHEMBL22099631 | 0.84 | DRD1 (0.57) | DRD1DRD5DRD3DRD2PRMT5 | |
| SCHEMBL22099626 | 0.82 | SLC6A2 (0.55) | DRD1DRD5DRD3DRD2SLC6A3 | |
| SCHEMBL3173969 | 0.82 | ABCB1 (0.68) | DRD1DRD5DRD3DRD2SLC6A3 | |
| SCHEMBL24110647 | 0.82 | DRD1 (0.55) | DRD1DRD5DRD3DRD2PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339896-A1 | HPK1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. | 2023-10-26 | — | — | US | disclosed |
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. | 2022-12-08 | — | — | US | disclosed |
| WO-2021000935-A1 | HPK1 INHIBITORS AND USES THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2021-01-07 | — | — | WO | disclosed |
| EP-2061763-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-16 | — | — | EP | disclosed |
| EP-2061763-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-16 | — | — | EP | disclosed |
| US-7872138-B2 | Process for the preparation of substituted-1,2,3,4-tetrahydroisoquinoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-18 | — | — | US | disclosed |
| US-7872138-B2 | Process for the preparation of substituted-1,2,3,4-tetrahydroisoquinoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-18 | — | — | US | disclosed |
| US-7872138-B2 | Process for the preparation of substituted-1,2,3,4-tetrahydroisoquinoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-18 | — | — | US | disclosed |
| WO-2008019356-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-02-14 | — | — | WO | disclosed |
| US-20080033177-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-02-07 | — | — | US | disclosed |
| US-20080033177-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-02-07 | — | — | US | disclosed |
| US-20080033177-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | HIPK1, SIK1, PGK1 | DRD1 4829/4885DRD5 4827/4885DRD3 4849/4885 |
| US-20080033177-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES | CYP3A4, CYP4B1, CYP3A5 | DRD1 79/4885DRD5 185/4885DRD3 154/4885 |
| US-20230339896-A1 | HPK1 INHIBITORS AND USES THEREOF | HIPK1, MAPKAPK5, MLKL | DRD1 4817/4885DRD5 4749/4885DRD3 4844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.