Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390063 | 0.96 | FFAR1 (0.38) | FFAR1PPARGPPARAALDH1A1CYP3A4 | |
| SCHEMBL4378233 | 0.94 | FFAR1 (0.39) | FFAR1ALDH1A1 | |
| SCHEMBL4394354 | 0.88 | HRH3 (0.38) | CYP2D6KCNH2 | |
| SCHEMBL4394357 | 0.88 | HRH3 (0.38) | CYP2D6KCNH2 | |
| SCHEMBL4383472 | 0.85 | ALDH1A1 (0.46) | FFAR1PPARGPPARAALDH1A1CYP4F2 | |
| SCHEMBL4383862 | 0.82 | ALDH1A1 (0.46) | FFAR1PPARGPPARAALDH1A1 | |
| SCHEMBL4378585 | 0.81 | ALDH1A1 (0.53) | FFAR1ALDH1A1CYP3A4 | |
| SCHEMBL7991257 | 0.81 | CYP3A4 (0.45) | ALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL647793 | 0.80 | FURIN (0.43) | KCNH2 | |
| SCHEMBL647792 | 0.80 | FURIN (0.43) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |