Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.52 |
| ▸ | VCP | P55072 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.49 |
| ▸ | RELA | Q04206 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4243648 | 0.78 | NPC1 (0.43) | SMN1; SMN2L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL7554523 | 0.75 | ALOX5 (0.84) | ALOX5SMN1; SMN2AMY1ANPY5RVCP | |
| SCHEMBL1822611 | 0.75 | SMN1; SMN2 (0.84) | ALOX5SMN1; SMN2AMY1ANPY5RVCP | |
| SCHEMBL2533440 | 0.75 | RAB9A (0.51) | ALOX5SMN1; SMN2VCPMAPTMEN1 | |
| SCHEMBL2532075 | 0.75 | NPC1 (0.67) | ALOX5SMN1; SMN2L3MBTL1MAPTMEN1 | |
| Bromide SCHEMBL7670429 | 0.74 | ALOX5 (0.82) | ALOX5SMN1; SMN2AMY1ANPY5RVCP | |
| SCHEMBL29152948 | 0.72 | ALOX5 (1.00) | ALOX5SMN1; SMN2AMY1ANPY5RVCP | |
| SCHEMBL369597 | 0.71 | APP (0.56) | SMN1; SMN2L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL1886135 | 0.71 | SMN1; SMN2 (1.00) | ALOX5SMN1; SMN2AMY1ANPY5RVCP | |
| SCHEMBL4064704 | 0.71 | NPC1 (0.62) | SMN1; SMN2L3MBTL1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010871-A2 | PYRAZOLE DERIVATIVES AS ANTAGONISTS OF ADENOSINE A3 RECEPTOR | ADDEX PHARMA S.A. (CH) | 2009-01-22 | — | — | WO | disclosed |