Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.47 |
| ▸ | SELE | P16581 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | RHEB | Q15382 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11546890 | 0.85 | PTGS1 (0.60) | PTGS1PTGS2CYP19A1ICAM1SELE | |
| SCHEMBL4373612 | 0.85 | GAA (0.46) | PTGS1PTGS2CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL4370948 | 0.80 | PTGS1 (0.52) | PTGS1PTGS2ICAM1SELEVCAM1 | |
| SCHEMBL4374807 | 0.80 | PTGS1 (0.50) | PTGS1PTGS2ICAM1SELECYP1A2 | |
| SCHEMBL633342 | 0.78 | GAA (0.64) | L3MBTL1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| Hydrochloric Acid SCHEMBL9853816 | 0.78 | PTGS1 (0.49) | PTGS1PTGS2ICAM1SELECYP1A2 | |
| SCHEMBL9853612 | 0.76 | GAA (0.65) | CYP19A1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL11545629 | 0.75 | LMNA (0.75) | PTGS1PTGS2CYP19A1LMNATDP1 | |
| SCHEMBL15392042 | 0.73 | CYP19A1 (0.56) | PTGS1PTGS2CYP19A1ICAM1SELE | |
| SCHEMBL7390045 | 0.72 | CYP1A2 (0.66) | CYP19A1L3MBTL1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432684-B1 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | UNIV LIEGE (BE) | 2009-03-25 | — | — | EP | disclosed |
| US-20070173534-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITE DE LIEGE | 2007-07-26 | — | — | US | disclosed |
| US-7226936-B2 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITY DE LIEGE (BE) | 2007-06-05 | — | — | US | disclosed |
| US-20050020642-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | UNIVERSITE DE LIEGE (BE) | 2005-01-27 | — | — | US | disclosed |
| EP-1432684-A2 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | University of Liege (BE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003029217-A2 | PYRIDINIC SULFONAMIDE DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | UNIVERSITE DE LIEGE (BE) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173534-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | PTGIS, ARSA, C3AR1 | PTGS1 4/4885PTGS2 13/4885CYP19A1 118/4885 |
| US-20050020642-A1 | Pyridinic sulfonamide derivatives method of production and use thereof | ARSA, PTGIS, C3AR1 | PTGS1 4/4885PTGS2 31/4885CYP19A1 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.