Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 2/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652453 | 1.00 | POLB (0.62) | POLBTSHRATMGAARAB9A | |
| SCHEMBL8932501 | 0.94 | HDAC1 (0.59) | POLBTSHRATMGAARAB9A | |
| SCHEMBL844471 | 0.90 | ITGB3 (0.58) | ACEACE2CTSK | |
| SCHEMBL2185240 | 0.90 | ITGB3 (0.58) | ACEACE2CTSK | |
| SCHEMBL7758997 | 0.90 | ITGB3 (0.58) | ACEACE2CTSK | |
| SCHEMBL9186008 | 0.90 | ACE (0.53) | POLBRAB9ABIRC2ACEACE2 | |
| SCHEMBL7361995 | 0.89 | ACE (0.55) | POLBGAARAB9AALDH1A1ACE | |
| SCHEMBL25007335 | 0.89 | ATM (0.58) | POLBTSHRATMGAARAB9A | |
| SCHEMBL10621045 | 0.89 | BIRC2 (0.55) | POLBTSHRATMGAARAB9A | |
| SCHEMBL1721283 | 0.88 | NPSR1 (0.53) | POLBTSHRALDH1A1CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121676-A1 | PREPERATION AND UTILITY OF CCR5 INHIBITORS | Auspex Pharmaceuticals, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008077103-A1 | PREPERATION AND UTILITY OF CCR5 INHIBITORS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |