Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392100 | 0.98 | GSK3B (0.35) | GSK3BNAMPTCYP3A4LATS1LATS2 | |
| SCHEMBL4384554 | 0.83 | GSK3B (0.37) | GSK3BCYP3A4CYP2D6 | |
| SCHEMBL4954713 | 0.82 | GSK3B (0.36) | GSK3BCYP3A4LATS1LATS2CYP2D6 | |
| SCHEMBL4377775 | 0.81 | GSK3B (0.39) | GSK3BLATS1LATS2CYP2D6HDAC1 | |
| SCHEMBL4378591 | 0.80 | GSK3B (0.38) | GSK3BCYP3A4CYP2D6 | |
| SCHEMBL4383569 | 0.78 | GSK3B (0.37) | GSK3BCYP3A4CYP2D6 | |
| SCHEMBL2066100 | 0.78 | GSK3B (0.43) | GSK3BCYP3A4CYP2D6 | |
| SCHEMBL4387999 | 0.77 | GSK3B (0.37) | GSK3BCYP3A4 | |
| SCHEMBL4384596 | 0.77 | GSK3B (0.37) | GSK3BNAMPTCYP3A4CYP2D6 | |
| SCHEMBL3373754 | 0.75 | OPRD1 (0.41) | GSK3BCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | claimed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | claimed |