Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 14/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372743 | 0.91 | CYP3A4 (0.38) | GSK3BCYP2D6CYP3A4TP53CYP1A2 | |
| SCHEMBL2065915 | 0.91 | GSK3B (0.37) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL2066113 | 0.91 | GSK3B (0.46) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL2066100 | 0.90 | GSK3B (0.43) | GSK3BCYP2D6CYP3A4KMT2ACYP1A2 | |
| SCHEMBL2065738 | 0.89 | SLC6A9 (0.46) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL2064528 | 0.86 | KCNMA1 (0.42) | GSK3BCYP2D6CYP3A4KMT2ACYP1A2 | |
| SCHEMBL2064564 | 0.86 | MEN1 (0.39) | GSK3BCYP2D6CYP3A4KMT2ACYP1A2 | |
| SCHEMBL2065135 | 0.86 | HTR4 (0.40) | CYP2D6KMT2A | |
| SCHEMBL4378591 | 0.84 | GSK3B (0.38) | GSK3BCYP2D6CYP3A4GAACYP1A2 | |
| SCHEMBL2067140 | 0.83 | GSK3B (0.42) | GSK3BCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957492-B1 | SUBSTITUTED BICYCLIC PYRIMIDONE DERIVATIVES | SANOFI AVENTIS (FR) | 2010-11-10 | — | — | EP | claimed |
| EP-1957492-A2 | SUBSTITUTED BICYCLIC PYRIMIDONE DERIVATIVES | sanofi-aventis (FR) | 2008-08-20 | — | — | EP | claimed |
| WO-2007057790-A2 | SUBSTITUTED BICYCLIC PYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2007-05-24 | — | — | WO | claimed |
| EP-1957492-A2 | SUBSTITUTED BICYCLIC PYRIMIDONE DERIVATIVES | sanofi-aventis (FR) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007057790-A2 | SUBSTITUTED BICYCLIC PYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2007-05-24 | — | — | WO | disclosed |