Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2065321 | 0.82 | KDM4E (0.43) | RAB9AMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL2065134 | 0.82 | GSK3B (0.46) | HPGDMAPTRAB9ANPC1 | |
| SCHEMBL2066272 | 0.79 | GRM5 (0.50) | RAB9ANPC1 | |
| SCHEMBL2065337 | 0.79 | SMN1; SMN2 (0.45) | HPGDMAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL3375649 | 0.78 | GSK3B (0.40) | MAPK1 | |
| SCHEMBL4386108 | 0.78 | RAB9A (0.41) | HPGDSMN1; SMN2RAB9AKMT2ANPC1 | |
| SCHEMBL2065605 | 0.77 | BRAF (0.39) | — | |
| SCHEMBL2064828 | 0.77 | GSK3B (0.50) | — | |
| SCHEMBL4390474 | 0.77 | ALDH1A1 (0.46) | HPGDMAPTSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL4391262 | 0.76 | ALDH1A1 (0.45) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198287-B2 | Substituted heteroaryl pyridopyrimidone derivatives | SANOFI-AVENTIS (FR) | 2012-06-12 | — | — | US | disclosed |
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | disclosed |