Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MLKL | Q8NB16 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033486 | 0.76 | CDK2 (0.49) | SMN1; SMN2PTGS2LMNAHPGDMAPK1 | |
| SCHEMBL2611063 | 0.74 | APP (0.35) | SMN1; SMN2MAPK1ALDH1A1ADORA2A | |
| SCHEMBL5033485 | 0.73 | SLC2A1 (0.41) | SMN1; SMN2PTGS2LMNAHPGDSLC2A1 | |
| SCHEMBL15071043 | 0.71 | APP (0.33) | MAPK1 | |
| Hydrochloric Acid SCHEMBL15055013 | 0.70 | APP (0.33) | MAPK1 | |
| SCHEMBL1750126 | 0.69 | NPC1 (0.49) | SMN1; SMN2LMNAMAPK1HDAC6CDK8 | |
| SCHEMBL20674568 | 0.68 | MAPK1 (0.39) | MAPK1HDAC6 | |
| SCHEMBL1493831 | 0.66 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAHPGDMAPK1ALDH1A1 | |
| SCHEMBL15820237 | 0.66 | ALDH1A1 (0.40) | HPGDMAPK1HDAC6ALDH1A1KDM4E | |
| SCHEMBL21804784 | 0.66 | HTR2C (0.40) | SMN1; SMN2PTGS2LMNAHPGDSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149458-A1 | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS | WYETH (US) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149458-A1 | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS | MTOR, PIK3CA, PIK3CD | SMN1; SMN2 2559/4885PTGS2 2251/4885LMNA 4677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.