Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | XDH | P47989 | 1/20 | 0.54 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.52 |
| ▸ | SYK | P43405 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4389627 | 0.91 | CDK2 (0.58) | CDK2RAB9AZAP70SYKKMT2A | |
| SCHEMBL4391861 | 0.87 | CDK2 (0.50) | CDK2SYKPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4387241 | 0.86 | LMNA (0.55) | CDK2KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL14216141 | 0.85 | SYK (0.70) | CDK2KDM4ESMN1; SMN2RAB9AZAP70 | |
| SCHEMBL27657614 | 0.81 | CDK2 (0.55) | CDK2ZAP70SYKPIK3CAPIK3CB | |
| SCHEMBL4385552 | 0.79 | SYK (0.50) | CDK2KDM4ESMN1; SMN2POLBRAB9A | |
| SCHEMBL4387753 | 0.79 | CDC7 (0.62) | CDK2KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL14378895 | 0.78 | CDK2 (0.70) | CDK2ZAP70SYKPIK3CAPIK3CB | |
| SCHEMBL4386260 | 0.78 | CDK2 (0.51) | CDK2KDM4EZAP70SYKPIK3CA | |
| SCHEMBL5310238 | 0.78 | CDK2 (0.56) | CDK2ZAP70SYKPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751146-B1 | PYRIDINYL- OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LTD (GB) | 2009-12-02 | — | — | EP | claimed |