Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 5/20 | 0.43 |
| ▸ | CDK9 | P50750 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 4/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4389830 | 0.91 | CDK2 (0.47) | CDK2PIK3CAPIK3CBPIK3CGZAP70 | |
| SCHEMBL4387241 | 0.84 | LMNA (0.55) | CDK2PIK3CAPIK3CBPIK3CGZAP70 | |
| SCHEMBL4395196 | 0.81 | CDC7 (0.41) | CDK2PIK3CGZAP70SYKSRC | |
| SCHEMBL4387753 | 0.79 | CDC7 (0.62) | CDK2PIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL4389627 | 0.78 | CDK2 (0.58) | CDK2PIK3CAPIK3CBPIK3CGZAP70 | |
| SCHEMBL4385796 | 0.78 | CDK2 (0.58) | CDK2PIK3CAPIK3CBPIK3CGZAP70 | |
| SCHEMBL27657614 | 0.76 | CDK2 (0.55) | CDK2PIK3CAPIK3CBPIK3CGZAP70 | |
| SCHEMBL5310238 | 0.74 | CDK2 (0.56) | CDK2PIK3CAPIK3CBPIK3CGZAP70 | |
| SCHEMBL14378895 | 0.73 | CDK2 (0.70) | CDK2PIK3CAPIK3CBPIK3CGZAP70 | |
| SCHEMBL27657616 | 0.71 | CDK2 (0.55) | CDK2PIK3CAPIK3CBPIK3CGZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751146-B1 | PYRIDINYL- OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LTD (GB) | 2009-12-02 | — | — | EP | claimed |