Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | MC2R | Q01718 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 6/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 6/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CDK7 | P50613 | 3/20 | 0.34 |
| ▸ | CCNH | P51946 | 3/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4241941 | 0.93 | HCRTR1 (0.44) | HCRTR1HCRTR2GFERCCNKCDK12 | |
| SCHEMBL4241934 | 0.93 | HCRTR1 (0.44) | HCRTR1HCRTR2GFERCCNKCDK12 | |
| SCHEMBL4394061 | 0.90 | MGLL (0.37) | MC2RMAPK10 | |
| SCHEMBL4392235 | 0.89 | GFER (0.41) | GFERCCNKCDK12CDK2CDK7 | |
| SCHEMBL8224528 | 0.84 | HCRTR1 (0.46) | HCRTR1HCRTR2GFERCCNKCDK12 | |
| SCHEMBL4249003 | 0.82 | GFER (0.42) | GFERCCNKCDK12CDK2CDK7 | |
| SCHEMBL4249000 | 0.82 | GFER (0.42) | GFERCCNKCDK12CDK2CDK7 | |
| SCHEMBL8224313 | 0.82 | MGLL (0.42) | — | |
| SCHEMBL4388248 | 0.82 | KDM5A (0.41) | HCRTR1HCRTR2MAPK10 | |
| SCHEMBL8227626 | 0.81 | GFER (0.45) | HCRTR1HCRTR2GFERCCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897627-B2 | Heteroaryl derivatives as orexin receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20090163485-A1 | HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163485-A1 | HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | HCRTR1, HCRTR2, MTNR1A | HCRTR1 1/4885HCRTR2 2/4885MC2R 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.