Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.55 |
| ▸ | FASN | P49327 | 3/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MGLL | Q99685 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TLR2 | O60603 | 1/20 | 0.50 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3650639 | 0.89 | CHRNB2 (0.61) | HPGDMEN1KMT2AALDH1A1CHRNB2 | |
| SCHEMBL20067667 | 0.87 | SMN1; SMN2 (0.65) | HPGDMAPK1SMN1; SMN2POLBMEN1 | |
| SCHEMBL20067709 | 0.87 | SMN1; SMN2 (0.65) | HPGDMAPK1SMN1; SMN2POLBMEN1 | |
| SCHEMBL4635281 | 0.87 | HPGD (0.58) | HPGDMAPK1SMN1; SMN2POLBMEN1 | |
| SCHEMBL8158994 | 0.84 | HPGD (0.64) | HPGDMAPK1SMN1; SMN2POLBMEN1 | |
| SCHEMBL15958971 | 0.83 | PLA2G1B (0.67) | HPGDMAPK1SMN1; SMN2POLBMEN1 | |
| SCHEMBL15172195 | 0.80 | PLA2G1B (0.77) | HPGDMAPK1SMN1; SMN2POLBMEN1 | |
| SCHEMBL10721898 | 0.80 | MAPK1 (0.85) | HPGDMAPK1SMN1; SMN2POLBMEN1 | |
| SCHEMBL8159153 | 0.79 | HPGD (0.78) | HPGDMAPK1SMN1; SMN2POLBMEN1 | |
| SCHEMBL17888327 | 0.79 | PKM (0.59) | HPGDMEN1KMT2AALDH1A1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054721-A1 | AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICAL NV (BE) | 2012-04-26 | — | — | WO | disclosed |