Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRE | P78334 | 1/20 | 0.32 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.32 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.32 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5059324 | 0.71 | SMAD3 (0.35) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL15920138 | 0.68 | GABRA1 (0.41) | MAP2K2MAP2K1GABRA1GABRG2GABRB3 | |
| SCHEMBL13242363 | 0.65 | MAP2K2 (0.38) | MAP2K2MAP2K1GABRA1GABRG2GABRB3 | |
| SCHEMBL13242294 | 0.64 | MAP2K2 (0.34) | MAP2K2MAP2K1GABRA1GABRG2GABRB3 | |
| SCHEMBL7574850 | 0.64 | SMAD3 (0.39) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL4626816 | 0.62 | TSHR (0.60) | MAP2K2MAP2K1GABRA1GABRG2GABRB3 | |
| SCHEMBL1207860 | 0.62 | CA12 (0.56) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL9541553 | 0.62 | ALDH1A1 (0.60) | MAP2K2MAP2K1GABRA1GABRG2GABRB3 | |
| SCHEMBL1840091 | 0.61 | TSHR (0.53) | MAP2K2MAP2K1GABRA1GABRG2GABRB3 | |
| SCHEMBL4149582 | 0.61 | TSHR (0.53) | MAP2K2MAP2K1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628990-B1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-20070141276-A1 | Novel 14 and 15 membered ring compounds | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | disclosed |
| EP-1628990-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004101588-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2004-11-25 | — | — | WO | disclosed |