Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003168 | 0.94 | FAAH (0.51) | FAAHSMARCA2SMARCA4MAPK1SMN1; SMN2 | |
| SCHEMBL3005756 | 0.90 | FAAH (0.57) | FAAHSMARCA2SMARCA4MAPK1SMN1; SMN2 | |
| SCHEMBL2999250 | 0.89 | FAAH (0.48) | FAAHSMARCA2SMARCA4MAPK1SMN1; SMN2 | |
| SCHEMBL2996494 | 0.87 | FAAH (0.46) | FAAHSMARCA2SMARCA4SMN1; SMN2LMNA | |
| SCHEMBL4375470 | 0.87 | FAAH (0.42) | FAAHSMARCA2SMARCA4SMN1; SMN2LMNA | |
| SCHEMBL3005605 | 0.87 | FAAH (0.52) | FAAHSMARCA2SMARCA4MAPK1SMN1; SMN2 | |
| SCHEMBL3003646 | 0.86 | FAAH (0.47) | FAAHSMARCA2SMARCA4MAPK1SMN1; SMN2 | |
| SCHEMBL4083369 | 0.85 | FAAH (0.48) | FAAHSMARCA2SMARCA4LMNAALDH1A1 | |
| SCHEMBL2993334 | 0.84 | FAAH (0.62) | FAAHSMARCA2SMARCA4PLA2G4A | |
| SCHEMBL4100722 | 0.83 | FAAH (0.47) | FAAHSMARCA2SMARCA4MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |