Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 4/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3005624 | 0.94 | FAAH (0.46) | FAAHL3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL4083369 | 0.89 | FAAH (0.48) | FAAHALDH1A1LMNAMAPTALOX12 | |
| SCHEMBL4386885 | 0.87 | FAAH (0.46) | FAAHL3MBTL1ALDH1A1LMNASMARCA2 | |
| SCHEMBL2999250 | 0.86 | FAAH (0.48) | FAAHL3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL3007953 | 0.85 | FAAH (0.57) | FAAHALDH1A1LMNAMAPTALOX12 | |
| SCHEMBL3005180 | 0.85 | JAK2 (0.42) | FAAHL3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL3006423 | 0.84 | LMNA (0.45) | FAAHALDH1A1LMNAMAPTALOX12 | |
| SCHEMBL3000300 | 0.84 | FAAH (0.43) | FAAHL3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL3006579 | 0.84 | FAAH (0.56) | FAAHALDH1A1LMNAMAPTSMARCA2 | |
| SCHEMBL3000204 | 0.83 | FAAH (0.51) | FAAHALDH1A1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |