Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387669 | 0.98 | ALDH1A1 (0.47) | ALDH1A1KDM4ERAB9AHPGDHSD17B10 | |
| SCHEMBL4387664 | 0.91 | ALDH1A1 (0.43) | ALDH1A1KDM4ERAB9AHPGDHSD17B10 | |
| SCHEMBL4390349 | 0.91 | LMNA (0.49) | ALDH1A1KDM4ERAB9AHPGDHSD17B10 | |
| SCHEMBL3812384 | 0.87 | ALDH1A1 (0.46) | ALDH1A1KDM4ERAB9AHPGDHSD17B10 | |
| SCHEMBL5441521 | 0.81 | LMNA (0.53) | ALDH1A1KDM4ERAB9AHPGDHSD17B10 | |
| SCHEMBL3815910 | 0.80 | LMNA (0.49) | ALDH1A1KDM4ERAB9AHPGDHSD17B10 | |
| SCHEMBL3983498 | 0.78 | ALDH1A1 (0.51) | ALDH1A1KDM4ERAB9AHPGDHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL3819812 | 0.77 | KDM4E (0.49) | ALDH1A1KDM4ERAB9AHPGDHSD17B10 | |
| SCHEMBL4544174 | 0.77 | KDM4E (0.50) | ALDH1A1KDM4ERAB9AHPGDHSD17B10 | |
| SCHEMBL3983514 | 0.76 | ALDH1A1 (0.51) | ALDH1A1KDM4ERAB9AHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628990-B1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-20070141276-A1 | Novel 14 and 15 membered ring compounds | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | disclosed |
| EP-1628990-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004101588-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2004-11-25 | — | — | WO | disclosed |