Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386475 | 0.94 | HPGD (0.38) | NAMPTHPGDGSK3BIRAK4CYP2C9 | |
| SCHEMBL4386979 | 0.89 | GSK3B (0.38) | NAMPTGSK3B | |
| SCHEMBL3659187 | 0.85 | P2RY12 (0.41) | HPGDGSK3BLMNAMAPK1 | |
| SCHEMBL4384596 | 0.84 | GSK3B (0.37) | NAMPTGSK3B | |
| SCHEMBL4383569 | 0.83 | GSK3B (0.37) | GSK3BLMNAPDE3BPDE3A | |
| SCHEMBL4377844 | 0.80 | MEN1 (0.45) | GSK3B | |
| SCHEMBL3403493 | 0.80 | GSK3B (0.35) | NAMPTGSK3B | |
| SCHEMBL4386384 | 0.77 | CYP2C9 (0.38) | HPGDGSK3BCHRNA7CYP2C9HTR3A | |
| SCHEMBL3664250 | 0.75 | GSK3B (0.43) | HPGDGSK3BLMNAMGLL | |
| SCHEMBL4391283 | 0.75 | CYP2C9 (0.39) | GSK3BIRAK4CYP2C9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | claimed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |