Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 5/20 | 0.35 |
| ▸ | CNR2 | P34972 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379543 | 0.89 | CYP1A2 (0.38) | CYP2C9MEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4391863 | 0.89 | MAPT (0.40) | CYP2C9MEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4952879 | 0.88 | MEN1 (0.47) | CYP2C9MEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4385766 | 0.87 | RAB9A (0.51) | CYP2C9MEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4380168 | 0.86 | GSK3B (0.38) | CYP1A2GSK3BCSNK1A1GSK3A | |
| SCHEMBL4386498 | 0.85 | ALDH1A1 (0.54) | CYP2C9MEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4383616 | 0.85 | MEN1 (0.47) | MEN1KMT2ACNR1CNR2PRKACA | |
| SCHEMBL4387186 | 0.83 | L3MBTL1 (0.56) | MEN1KMT2AKDM4EGAAL3MBTL1 | |
| SCHEMBL4388471 | 0.83 | KDM4E (0.47) | ALDH1A1KDM4EGAAL3MBTL1 | |
| SCHEMBL4377829 | 0.83 | ALDH1A1 (0.45) | CYP2C9MEN1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | claimed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |