Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 9/20 | 0.84 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.71 |
| ▸ | PRKACA | P17612 | 4/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | WNT3A | P56704 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL439696 | 0.92 | CYP3A4 (0.72) | CYP3A4ROCK1PRKACAHTTMEN1 | |
| SCHEMBL438700 | 0.91 | CYP3A4 (1.00) | CYP3A4ROCK1PRKACAHTTMEN1 | |
| SCHEMBL437424 | 0.89 | ROCK1 (0.78) | CYP3A4ROCK1PRKACAWNT3A | |
| SCHEMBL439413 | 0.87 | ROCK1 (0.77) | CYP3A4ROCK1PRKACAHTTWNT3A | |
| SCHEMBL439403 | 0.87 | ROCK1 (0.77) | CYP3A4ROCK1PRKACAHTTWNT3A | |
| SCHEMBL439408 | 0.87 | ROCK1 (0.77) | CYP3A4ROCK1PRKACAMEN1KMT2A | |
| SCHEMBL437420 | 0.86 | ROCK1 (0.78) | CYP3A4ROCK1PRKACAHTTWNT3A | |
| SCHEMBL439699 | 0.85 | CYP3A4 (0.78) | CYP3A4ROCK1PRKACAHTTWNT3A | |
| SCHEMBL437318 | 0.85 | CYP3A4 (0.72) | CYP3A4ROCK1PRKACAMEN1KMT2A | |
| SCHEMBL438705 | 0.85 | CYP3A4 (0.88) | CYP3A4ROCK1PRKACAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278306-B2 | C-met protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-02 | — | — | US | disclosed |
| US-20120065213-A1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065213-A1 | C-MET PROTEIN KINASE INHIBITORS | MET, PRKCH, MYLK | CYP3A4 3859/4885ROCK1 4/4885PRKACA 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.