Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.57 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.57 |
| ▸ | CTSD | P07339 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP7 | P09237 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | MME | P08473 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15345879 | 0.92 | LTA4H (0.62) | LTA4HMMP2MMP7MMP9MMP12 | |
| SCHEMBL32667937 | 0.90 | BACE1 (0.66) | BACE1BACE2CTSDLTA4HMMP2 | |
| SCHEMBL30905993 | 0.90 | BACE1 (0.61) | BACE1BACE2CTSDLTA4HMME | |
| SCHEMBL30804672 | 0.88 | BACE1 (0.69) | BACE1BACE2CTSD | |
| Glutamic Acid SCHEMBL4387195 | 0.88 | NAALAD2 (0.64) | LTA4HMME | |
| D-Glutamate SCHEMBL4387193 | 0.88 | NAALAD2 (0.64) | LTA4HMME | |
| SCHEMBL25409107 | 0.87 | NAALAD2 (0.57) | MME | |
| SCHEMBL30803739 | 0.87 | NAALAD2 (0.61) | BACE1BACE2CTSDMME | |
| SCHEMBL29641835 | 0.85 | BACE1 (0.69) | BACE1BACE2CTSD | |
| SCHEMBL3732243 | 0.85 | NAALAD2 (0.68) | BACE1BACE2MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10175233-B2 | Biomarkers for cardiovascular diseases and methods using the same | METABOLON, INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20160178620-A1 | Biomarkers for Pre-Diabetes, Cardiovascular Diseases, and other Metabolic-Syndrome Related Disorders and Methods Using the Same | METABOLON, INC. | 2016-06-23 | — | — | US | disclosed |
| US-8546098-B2 | Biomarkers for monitoring insulin resistance and methods using the same | METABOLON, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20120208215-A1 | Biomarkers for Pre-Diabetes, Cardiovascular Diseases, and Other Metabolic-Syndrome Related Disorders and Methods Using the Same | METABOLON, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-8187830-B2 | Method for determining insulin sensitivity with biomarkers | METABOLON, INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090155826-A1 | Biomarkers for pre-diabetes, cardiovascular diseases, and other metabolic-syndrome related disorders and methods using the same | METABOLON, INC. (US) | 2009-06-18 | — | — | US | disclosed |