Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CTSS | P25774 | 7/20 | 0.47 |
| ▸ | CTSK | P43235 | 7/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11901619 | 1.00 | KMT2A (0.53) | KMT2ACTSSCTSKCA1CA2 | |
| SCHEMBL6234092 | 1.00 | KMT2A (0.53) | KMT2ACTSSCTSKCA1CA2 | |
| SCHEMBL29918018 | 0.88 | KMT2A (0.55) | KMT2ACTSSCTSKCA1CA2 | |
| SCHEMBL10841914 | 0.87 | KMT2A (0.53) | KMT2ACTSSCTSKCA1CA2 | |
| SCHEMBL8536884 | 0.87 | KMT2A (0.57) | KMT2ACTSSCTSKCA1CA2 | |
| SCHEMBL8536880 | 0.87 | KMT2A (0.57) | KMT2ACTSSCTSKCA1CA2 | |
| SCHEMBL10760962 | 0.87 | KMT2A (0.57) | KMT2ACTSSCTSKCA1CA2 | |
| SCHEMBL28827213 | 0.87 | KMT2A (0.53) | KMT2ACTSSCTSKCA1CA2 | |
| SCHEMBL26419810 | 0.87 | KMT2A (0.53) | KMT2ACTSSCTSKCA1CA2 | |
| SCHEMBL31517881 | 0.86 | KMT2A (0.56) | KMT2ACTSSCTSKCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073868-B2 | Benzazepine derivatives useful as vasopressin antagonists | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-07-07 | — | — | US | disclosed |
| US-8785386-B2 | Benzazepine derivatives useful as vasopressin antagonists | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-07-22 | — | — | US | disclosed |
| US-8669229-B2 | Benzazepine derivatives useful as vasopressin antagonists | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-03-11 | — | — | US | disclosed |
| US-20140024640-A1 | Benzazepine Derivatives Useful as Vasopressin Antagonists | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-01-23 | — | — | US | disclosed |
| US-20140024619-A1 | Benzazepine Derivatives Useful as Vasopressin Antagonists | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-01-23 | — | — | US | disclosed |
| US-20110071084-A1 | BENZAZEPINE DERIVATIVES USEFUL AS VASOPRESSIN ANTAGONISTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-03-24 | — | — | US | disclosed |
| US-7612075-B2 | Substituted oxoazaheterocyclyl compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-20040102450-A1 | Substituted oxoazaheterocyclyl compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2004-05-27 | — | — | US | disclosed |
| EP-1208097-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | Aventis Pharmaceuticals Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001007436-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102450-A1 | Substituted oxoazaheterocyclyl compounds | F13B, F9, F11 | KMT2A 2513/4885CTSS 1128/4885CTSK 371/4885 |
| US-20110071084-A1 | BENZAZEPINE DERIVATIVES USEFUL AS VASOPRESSIN ANTAGONISTS | AVPR2, AVPR1B, AVPR1A | KMT2A 593/4885CTSS 2049/4885CTSK 2472/4885 |
| US-20140024619-A1 | Benzazepine Derivatives Useful as Vasopressin Antagonists | AVPR2, AVPR1B, AVPR1A | KMT2A 637/4885CTSS 2073/4885CTSK 2497/4885 |
| US-20140024640-A1 | Benzazepine Derivatives Useful as Vasopressin Antagonists | AVPR2, AVPR1B, AVPR1A | KMT2A 637/4885CTSS 2073/4885CTSK 2497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.