SCHEMBL8536880

SCHEMBL8536880

CC(NC(=O)OC(C)(C)C)C(=O)NCC(=O)O

nearest known ligand 0.69

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.57
CTSS P25774 9/20 0.50
CTSK P43235 9/20 0.50
CTSL P07711 1/20 0.48
CTSB P07858 1/20 0.48
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA7 P43166 1/20 0.46
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
PTGS2 P35354 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
ATM Q13315 1/20 0.42
GLS O94925 1/20 0.42
CYP2D6 P10635 1/20 0.42
MEN1 O00255 1/20 0.41
GAA P10253 1/20 0.41
ECE1 P42892 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8536884 1.00 KMT2A (0.57) KMT2ACTSSCTSKCTSLCTSB
SCHEMBL10760962 1.00 KMT2A (0.57) KMT2ACTSSCTSKCTSLCTSB
SCHEMBL31506338 0.94 KMT2A (0.52) KMT2ACTSSCTSKCTSLCTSB
SCHEMBL29918018 0.88 KMT2A (0.55) KMT2ACTSSCTSKCTSLCTSB
SCHEMBL11901619 0.87 KMT2A (0.53) KMT2ACTSSCTSKCTSLCTSB
SCHEMBL6234092 0.87 KMT2A (0.53) KMT2ACTSSCTSKCTSLCTSB
SCHEMBL4388913 0.87 KMT2A (0.53) KMT2ACTSSCTSKCTSLCTSB
SCHEMBL10841914 0.87 KMT2A (0.53) KMT2ACTSSCTSKCTSLCTSB
SCHEMBL28827213 0.87 KMT2A (0.53) KMT2ACTSSCTSKCTSLCTSB
SCHEMBL26419810 0.87 KMT2A (0.53) KMT2ACTSSCTSKCTSLCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260091024-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN THERAPEUTICS LTD (US) 2026-04-02 US disclosed
US-20260041673-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN THERAPEUTICS LTD (US) 2026-02-12 US disclosed
US-12472165-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-11-18 US disclosed
US-20250332148-A1 RILUZOLE PRODRUGS AND THEIR USE BIOHAVEN THERAPEUTICS LTD (US) 2025-10-30 US disclosed
US-20250304563-A1 ACTIVATORS OF EFFECTOR T CELLS ORUM THERAPEUTICS, INC. (KR) 2025-10-02 US disclosed
US-12295942-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-05-13 US disclosed
US-12213965-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-02-04 US disclosed
EP-4490152-A1 ACTIVATORS OF EFFECTOR T CELLS Orum Therapeutics Inc. (KR) 2025-01-15 EP disclosed
US-12005046-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2024-06-11 US disclosed
US-12005047-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2024-06-11 US disclosed
CN-107567438-A Riluzole prodrug and application thereof 拜尔哈文制药股份有限公司 2018-01-09 CN disclosed
US-9169295-B2 Macrocycles and macrocycle stabilized peptides BRISTOL-MYERS SQUIBB COMPANY (US) 2015-10-27 US disclosed
EP-2627662-B1 METHODS FOR PREPARING MACROCYCLES AND MACROCYCLE STABILIZED PEPTIDES BRISTOL MYERS SQUIBB CO (US) 2015-09-16 EP disclosed
CN-101928326-B Substitution five-heterocyclic alkyl aminoacyl compound and application thereof INST PHARM & TOXICOLOGY AMMS 2015-07-08 CN disclosed
US-20130281657-A1 MACROCYCLES AND MACROCYCLE STABILIZED PEPTIDES BRISTOL-MYERS SQUIBB COMPANY (US) 2013-10-24 US disclosed
CN-101928326-A Substitution five-heterocyclic alkyl aminoacyl compound and application thereof INST PHARM & TOXICOLOGY AMMS 2010-12-29 CN disclosed
US-5750555-A NERVOUS SYSTEM DISORDERS; SKIN DISORDERS; IMMUNOLOGY GOEDECKE AKTIENGESELLSCHAFT (DE) 1998-05-12 US disclosed
EP-0674632-A1 AMINOACID DERIVATIVES OF HETEROCYCLES AS PROTEIN KINASE C INHIBITORS GÖDECKE AKTIENGESELLSCHAFT (DE) 1995-10-04 EP disclosed
WO-1994014798-A1 AMINOACID DERIVATIVES OF HETEROCYCLES AS PROTEIN KINASE C INHIBITORS Gödecke Aktiengesellschaft (DE) 1994-07-07 WO disclosed
US-3991041-A GROWTH HORMONE RELEASE INHIBITOR AMERICAN HOME PRODUCTS CORPORATION (US) 1976-11-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260091024-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE IL6ST, GFRA3, GFRA1 KMT2A 3288/4885CTSS 1265/4885CTSK 1499/4885
US-12005046-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 KMT2A 2213/4885CTSS 653/4885CTSK 586/4885
US-20250304563-A1 ACTIVATORS OF EFFECTOR T CELLS CBLB, CBL, CBLC KMT2A 1486/4885CTSS 874/4885CTSK 715/4885
US-12005047-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 KMT2A 2213/4885CTSS 653/4885CTSK 586/4885
US-20260041673-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE GFRA3, IL6ST, GFRA1 KMT2A 3363/4885CTSS 1454/4885CTSK 1659/4885
US-12472165-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 KMT2A 2213/4885CTSS 653/4885CTSK 586/4885
US-12295942-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 KMT2A 2213/4885CTSS 653/4885CTSK 586/4885
US-20130281657-A1 MACROCYCLES AND MACROCYCLE STABILIZED PEPTIDES PTMS, VIP, MTPN KMT2A 3949/4885CTSS 176/4885CTSK 492/4885
US-20250332148-A1 RILUZOLE PRODRUGS AND THEIR USE APEH, ALDH1A2, UGT1A9 KMT2A 2213/4885CTSS 653/4885CTSK 586/4885
US-12213965-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 KMT2A 2213/4885CTSS 653/4885CTSK 586/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.