Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380468 | 0.90 | PTPN1 (0.40) | HSP90AA1HSP90AB1LMNAPTPN1DPP4 | |
| SCHEMBL4371884 | 0.81 | PTPN1 (0.41) | PTPN1DPP4CNR1CNR2 | |
| SCHEMBL3735387 | 0.78 | PTPN11 (0.30) | — | |
| SCHEMBL3734163 | 0.76 | PTPN1 (0.37) | HSP90AA1PTPN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL3734371 | 0.75 | PDE2A (0.32) | LMNAPTPN1SMN1; SMN2 | |
| SCHEMBL3737667 | 0.74 | ASIC3 (0.40) | HSP90AA1LMNAMAPTMEN1KMT2A | |
| SCHEMBL3734730 | 0.72 | PTPN1 (0.41) | PTPN1HSD11B1 | |
| SCHEMBL3727498 | 0.72 | F2RL3 (0.33) | PTPN1 | |
| SCHEMBL4511454 | 0.72 | HTR2B (0.35) | HSD11B1DPP4CNR2DPP8 | |
| SCHEMBL3737121 | 0.71 | PTPN1 (0.43) | PTPN1HSD11B1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |