Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TYMS | P04818 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 3/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4389735 | 0.90 | HSP90AA1 (0.42) | PTPN1DPP4DPP8CNR2HSP90AA1 | |
| SCHEMBL4371884 | 0.81 | PTPN1 (0.41) | PTPN1DPP4PTPN11IDO1CNR2 | |
| SCHEMBL3735387 | 0.80 | PTPN11 (0.30) | PTPN11 | |
| SCHEMBL4511454 | 0.79 | HTR2B (0.35) | HTR2BPDE4DDPP4DPP8PTPN11 | |
| SCHEMBL3734163 | 0.76 | PTPN1 (0.37) | PTPN1IDO1CNR2HSP90AA1 | |
| SCHEMBL3734371 | 0.75 | PDE2A (0.32) | PTPN1LMNAPDE2APDE10A | |
| SCHEMBL3737667 | 0.74 | ASIC3 (0.40) | ALDH1A1HSP90AA1LMNAPKM | |
| SCHEMBL3734730 | 0.72 | PTPN1 (0.41) | PTPN1 | |
| SCHEMBL3727498 | 0.72 | F2RL3 (0.33) | PTPN1 | |
| SCHEMBL4374306 | 0.71 | DHFR (0.41) | ALDH1A1PKMPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |