Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | DPP4 | P27487 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM6B | O15054 | 1/20 | 0.52 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.52 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4389868 | 1.00 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBDPP4GAACYP1A2 | |
| SCHEMBL1100902 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBDPP4GAACYP1A2 | |
| SCHEMBL29170274 | 0.85 | RAB9A (0.56) | SMN1; SMN2POLBDPP4GAACYP1A2 | |
| SCHEMBL7994938 | 0.84 | POLB (0.62) | SMN1; SMN2POLBDPP4GAACYP1A2 | |
| SCHEMBL5100760 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBDPP4GAACYP1A2 | |
| SCHEMBL5091651 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBDPP4GAACYP1A2 | |
| Oxalic Acid SCHEMBL7426081 | 0.83 | POLB (0.57) | SMN1; SMN2POLBDPP4GAACYP1A2 | |
| SCHEMBL29395449 | 0.82 | POLB (0.63) | SMN1; SMN2POLBDPP4GAACYP1A2 | |
| Hydrochloric Acid SCHEMBL5091570 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2POLBDPP4GAACYP1A2 | |
| SCHEMBL5089387 | 0.81 | POLB (0.53) | SMN1; SMN2POLBDPP4GAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125811-B1 | N-(AMINO-HETEROARYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDES DERIVATIVES, PREPARATION THEREOF AND THEIR USE IN THERAPY | SANOFI SA (FR) | 2013-05-29 | — | — | EP | disclosed |
| EP-2125811-A2 | N-(AMINO-HETEROARYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDES DERIVATIVES, PREPARATION THEREOF AND THEIR USE IN THERAPY | Sanofi-Aventis (FR) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008093024-A2 | N-(AMINO-HETEROARYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDES DERIVATIVES, PREPARATION THEREOF AND THEIR USE IN THERAPY | SANOFI-AVENTIS (FR) | 2008-08-07 | — | — | WO | disclosed |