Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | DPP4 | P27487 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29395449 | 0.90 | POLB (0.63) | POLBALDH1A1DPP4SMN1; SMN2GAA | |
| SCHEMBL7233175 | 0.87 | GAA (0.65) | POLBALDH1A1DPP4SMN1; SMN2GAA | |
| SCHEMBL22371621 | 0.87 | MAPT (0.56) | POLBALDH1A1DPP4SMN1; SMN2GAA | |
| SCHEMBL6697154 | 0.86 | ALDH1A1 (0.63) | POLBALDH1A1DPP4SMN1; SMN2GAA | |
| SCHEMBL4389868 | 0.84 | SMN1; SMN2 (0.59) | POLBALDH1A1DPP4SMN1; SMN2GAA | |
| SCHEMBL4389872 | 0.84 | SMN1; SMN2 (0.59) | POLBALDH1A1DPP4SMN1; SMN2GAA | |
| SCHEMBL13947445 | 0.83 | POLB (0.60) | POLBALDH1A1DPP4SMN1; SMN2GAA | |
| SCHEMBL5091559 | 0.83 | POLB (0.60) | POLBALDH1A1DPP4SMN1; SMN2GAA | |
| SCHEMBL5100760 | 0.82 | SMN1; SMN2 (0.60) | POLBALDH1A1DPP4SMN1; SMN2GAA | |
| Oxalic Acid SCHEMBL7426081 | 0.82 | POLB (0.57) | POLBALDH1A1DPP4SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001077077-A1 | SUBSTITUTED (HETERO)ARYL CARBOXAMIDE DERIVATIVES AS MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) AND APOLIPOPROTEIN B (APO B) SECRETION | NOVARTIS AG (CH) | 2001-10-18 | — | — | WO | disclosed |