Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 20/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 19/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 11/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869382 | 0.79 | PTGS2 (0.47) | PTGS2PTGS1ALOX5 | |
| SCHEMBL4613161 | 0.76 | PTGS2 (0.50) | PTGS2PTGS1ALOX5 | |
| SCHEMBL4612261 | 0.74 | PTGS2 (0.48) | PTGS2PTGS1ALOX5 | |
| SCHEMBL4612630 | 0.73 | PTGS2 (0.47) | PTGS2PTGS1ALOX5 | |
| SCHEMBL4612808 | 0.71 | PTGS2 (0.47) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6758656 | 0.71 | PTGS2 (0.47) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6593328 | 0.70 | PTGS2 (0.62) | PTGS2PTGS1ALOX5 | |
| SCHEMBL4612372 | 0.68 | PTGS2 (0.63) | PTGS2PTGS1ALOX5 | |
| SCHEMBL4612419 | 0.67 | PTGS2 (0.44) | PTGS2PTGS1ALOX5 | |
| SCHEMBL7799595 | 0.67 | PTGS2 (0.51) | PTGS2PTGS1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1892239-B1 | Inhibitors of cytosolic phospholipase A2 | WYETH LLC (US) | 2013-02-20 | — | — | EP | disclosed |
| EP-1797104-B1 | DERIVATIVES OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ALKYL]PHOSPHONIC ACID AND METHOD OF MAKING THEM | WYETH CORP (US) | 2009-11-25 | — | — | EP | disclosed |
| EP-1892239-A1 | Inhibitors of cytosolic phospholipase A2 | Wyeth a Corporation of the State of Delaware (US) | 2008-02-27 | — | — | EP | disclosed |
| EP-0773939-B1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | UNIV VANDERBILT (US) | 2008-02-06 | — | — | EP | disclosed |
| EP-1451154-B1 | INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | WYETH CORP (US) | 2008-01-16 | — | — | EP | disclosed |