Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 2/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375123 | 0.93 | PTPN1 (0.44) | PTPN1LTA4HPTGS2EGLN1 | |
| SCHEMBL4373575 | 0.92 | PTPN1 (0.43) | PTPN1LTA4HPTGS2 | |
| SCHEMBL4384842 | 0.91 | PTPN1 (0.42) | PTPN1 | |
| SCHEMBL4378695 | 0.90 | PTPN1 (0.41) | PTPN1 | |
| SCHEMBL4386942 | 0.89 | PTPN1 (0.40) | PTPN1 | |
| SCHEMBL4378503 | 0.88 | PTPN1 (0.48) | PTPN1HTR2AHTR2CHTR2B | |
| SCHEMBL3742273 | 0.86 | PTPN1 (0.36) | PTPN1KDM1AHTR2AHTR2CHTR2B | |
| SCHEMBL4384579 | 0.85 | PTPN1 (0.37) | PTPN1HTR2AHTR2CHTR2B | |
| SCHEMBL4379622 | 0.85 | PTPN1 (0.37) | PTPN1HTR2AHTR2CHTR2B | |
| SCHEMBL4384328 | 0.83 | PTPN1 (0.36) | PTPN1LTA4HPTGS2DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |