Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.37 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.31 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384328 | 0.92 | PTPN1 (0.36) | PTPN1CTSSHTR2AHTR2CHTR2B | |
| SCHEMBL4381198 | 0.89 | PTPN1 (0.38) | PTPN1HTR2AHTR2CHTR2B | |
| SCHEMBL4378503 | 0.89 | PTPN1 (0.48) | PTPN1HTR2AHTR2CHTR2B | |
| SCHEMBL4381287 | 0.88 | CTSS (0.36) | PTPN1CTSSCTSK | |
| SCHEMBL4380448 | 0.88 | LTA4H (0.43) | HTR2AHTR2CHTR2B | |
| SCHEMBL3742273 | 0.87 | PTPN1 (0.36) | PTPN1HTR2AHTR2CHTR2BTLR8 | |
| SCHEMBL4377822 | 0.87 | MAP4K1 (0.38) | SCN9AIKBKB | |
| SCHEMBL4379622 | 0.86 | PTPN1 (0.37) | PTPN1HTR2AHTR2CHTR2BS1PR1 | |
| SCHEMBL4373757 | 0.85 | HTR2A (0.38) | PTPN1HTR2AHTR2CHTR2B | |
| SCHEMBL4389955 | 0.85 | PTPN1 (0.51) | PTPN1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |