Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GUCY1A1 | Q02108 | 9/20 | 0.44 |
| ▸ | GUCY1B1 | Q02153 | 9/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4001274 | 0.86 | KEAP1 (0.58) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL27799338 | 0.85 | KEAP1 (0.57) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL4391021 | 0.84 | GUCY1A1 (0.54) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL15168580 | 0.84 | KEAP1 (0.48) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL2730298 | 0.84 | GUCY1A1 (0.52) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL16855053 | 0.83 | GUCY1A1 (0.66) | GUCY1A1GUCY1B1 | |
| SCHEMBL16855254 | 0.83 | GUCY1A1 (0.48) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL16835714 | 0.82 | GUCY1A1 (0.47) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL15187962 | 0.82 | GUCY1A1 (0.51) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL15168645 | 0.82 | GUCY1A1 (0.47) | KEAP1NFE2L2MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058132-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |