Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | GUCY1A1 | Q02108 | 11/20 | 0.47 |
| ▸ | GUCY1B1 | Q02153 | 11/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4001274 | 0.89 | KEAP1 (0.58) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL10182607 | 0.86 | KEAP1 (0.59) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL1780792 | 0.86 | GUCY1A1 (0.64) | KEAP1NFE2L2MEN1KMT2APOLB | |
| SCHEMBL4390119 | 0.85 | KEAP1 (0.54) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL3998254 | 0.83 | KEAP1 (0.67) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL3997434 | 0.82 | KEAP1 (0.57) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL22588240 | 0.82 | KEAP1 (0.49) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL3997788 | 0.80 | KEAP1 (0.65) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL2364934 | 0.79 | MEN1 (0.70) | KEAP1NFE2L2MEN1KMT2ARAB9A | |
| SCHEMBL27799412 | 0.79 | KEAP1 (0.59) | KEAP1NFE2L2MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101939053-A | Soluble guanylate cyclase activators | MERCK SHARP & DOHME | 2011-01-05 | — | — | CN | disclosed |